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Laryngeal cancer risk in Caucasians is associated with alcohol and tobacco consumption but not modified by genetic polymorphisms in class I alcohol dehydrogenases ADH1B and ADH1C, and glutathione-S-transferases GSTM1 and GSTT1.
Risch A, Ramroth H, Raedts V, Rajaee-Behbahani N, Schmezer P, Bartsch H, Becher H, Dietz A. Risch A, et al. Pharmacogenetics. 2003 Apr;13(4):225-30. doi: 10.1097/00008571-200304000-00007. Pharmacogenetics. 2003. PMID: 12668919
METHODS: Two hundred and forty-five cases and 251 population-based controls, matched by age and gender, were genotyped for genetic polymorphisms in ADH1B, ADH1C, GSTM1 and GSTT1, using genomic DNA isolated from peripheral lymphocytes and employing PCR and PCR/restri …
METHODS: Two hundred and forty-five cases and 251 population-based controls, matched by age and gender, were genotyped for genetic polymorph …
Genetic Association and Gene-Gene Interaction Reveal Genetic Variations in ADH1B, GSTM1 and MnSOD Independently Confer Risk to Alcoholic Liver Diseases in India.
Roy N, Dasgupta D, Mukhopadhyay I, Chatterjee A, Das K, Bhowmik P, Das S, Basu P, Santra AK, Datta S, Dhali GK, Chowdhury A, Banerjee S. Roy N, et al. PLoS One. 2016 Mar 3;11(3):e0149843. doi: 10.1371/journal.pone.0149843. eCollection 2016. PLoS One. 2016. PMID: 26937962 Free PMC article.
Out of 14 genetic variants, carriage of 5 genotypes (rs2066701CC in ADH1B, rs1693425TT in ADH1C, rs4880TT in MnSOD and GSTT1/GSTM1 null, p-value <0.05) were noted significantly higher among ALD patients while inter or intra group gene-gene interaction analysis re …
Out of 14 genetic variants, carriage of 5 genotypes (rs2066701CC in ADH1B, rs1693425TT in ADH1C, rs4880TT in MnSOD and GSTT1/GSTM1 …
Understanding breast cancer risk -- where do we stand in 2005?
Dumitrescu RG, Cotarla I. Dumitrescu RG, et al. J Cell Mol Med. 2005 Jan-Mar;9(1):208-21. doi: 10.1111/j.1582-4934.2005.tb00350.x. J Cell Mol Med. 2005. PMID: 15784178 Free PMC article. Review.
Additionally, we summarized breast cancer risk associated with the following genetic factors: breast cancer susceptibility high-penetrance genes (BRCA1, BRCA2, p53, PTEN, ATM, NBS1 or LKB1) and low-penetrance genes such as cytochrome P450 genes (CYP1A1, CYP2D6, CYP19), glutathion …
Additionally, we summarized breast cancer risk associated with the following genetic factors: breast cancer susceptibility high-penetrance g …
A review of genetic epidemiology of head and neck cancer related to polymorphisms in metabolic genes, cell cycle control and alcohol metabolism.
Cadoni G, Boccia S, Petrelli L, Di Giannantonio P, Arzani D, Giorgio A, De Feo E, Pandolfini M, Gallì P, Paludetti G, Ricciardi G. Cadoni G, et al. Acta Otorhinolaryngol Ital. 2012 Feb;32(1):1-11. Acta Otorhinolaryngol Ital. 2012. PMID: 22500060 Free PMC article. Review.
Among these, a statistically significant association was reported for glutathione S-transferases (GSTM1), glutathione S-transferases (GSTT1) and human microsomal epoxide hydrolase (EPHX1) genes. An increased risk for HNC was also associated reported for P53 codon 72 Pro/Pr …
Among these, a statistically significant association was reported for glutathione S-transferases (GSTM1), glutathione S-transferases …
Sequence Variants and the Risk of Head and Neck Cancer: Pooled Analysis in the INHANCE Consortium.
Chuang SC, Agudo A, Ahrens W, Anantharaman D, Benhamou S, Boccia S, Chen C, Conway DI, Fabianova E, Hayes RB, Healy CM, Holcatova I, Kjaerheim K, Lagiou P, Lazarus P, Macfarlane TV, Mahimkar MB, Mates D, Matsuo K, Merletti F, Metspalu A, Morgenstern H, Muscat J, Cadoni G, Olshan AF, Purdue M, Ramroth H, Rudnai P, Schwartz SM, Simonato L, Smith EM, Sturgis EM, Szeszenia-Dabrowska N, Talamini R, Thomson P, Wei Q, Zaridze D, Zhang ZF, Znaor A, Brennan P, Boffetta P, Hashibe M. Chuang SC, et al. Front Oncol. 2011 Jul 12;1:13. doi: 10.3389/fonc.2011.00013. eCollection 2011. Front Oncol. 2011. PMID: 22655231 Free PMC article.
Among these results, MGMT Leu84Phe, ADH1B Arg48His, ADH1C Ile350Arg, and the GSTM1 null genotype had fairly low false positive report probabilities (<20%). We observed associations between ADH1B Arg48His, ADH1C Ile350Arg, and GSTM1 null genotype and …
Among these results, MGMT Leu84Phe, ADH1B Arg48His, ADH1C Ile350Arg, and the GSTM1 null genotype had fairly low false positive …
Association of polymorphism in alcohol dehydrogenase and interaction with other genetic risk factors with alcoholic liver cirrhosis.
Khan AJ, Husain Q, Choudhuri G, Parmar D. Khan AJ, et al. Drug Alcohol Depend. 2010 Jun 1;109(1-3):190-7. doi: 10.1016/j.drugalcdep.2010.01.010. Epub 2010 Feb 18. Drug Alcohol Depend. 2010. PMID: 20171022
Our data revealed that the ADH1C*1/*1 genotype exhibited significant association with alcoholic liver cirrhosis while ADH1B genotypes did not show any significant association. A much higher risk to alcoholic liver cirrhosis was observed in patients carrying a combination o …
Our data revealed that the ADH1C*1/*1 genotype exhibited significant association with alcoholic liver cirrhosis while ADH1B genotypes …
Polymorphisms in metabolizing enzymes and the risk of head and neck squamous cell carcinoma in the Slavic population of the central Europe.
Soucek P, Susova S, Mohelnikova-Duchonova B, Gromadzinska J, Moraviec-Sztandera A, Vodicka P, Vodickova L. Soucek P, et al. Neoplasma. 2010;57(5):415-21. doi: 10.4149/neo_2010_05_415. Neoplasma. 2010. PMID: 20568895
The question of susceptibility to squamous cell carcinoma of head and neck (SCCHN) in the environmental context was addressed by analysis of functional polymorphisms in enzymes metabolizing smoke constituents and/or alcohol (CYP2A13, CYP1B1, EPHX1, NQO1, GSTM1, GSTP1, GSTT …
The question of susceptibility to squamous cell carcinoma of head and neck (SCCHN) in the environmental context was addressed by analysis of …